BAIT
OBSL1
obscurin-like 1
GO Process (7)
GO Function (2)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SCIN
scinderin
GO Process (8)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- actin filament severing [IMP]
- actin nucleation [ISS]
- calcium ion-dependent exocytosis [ISS]
- negative regulation of cell proliferation [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of megakaryocyte differentiation [IMP]
- positive regulation of secretion [ISS]
- regulation of chondrocyte differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identifying biological pathways that underlie primordial short stature using network analysis.
Mutations in CUL7, OBSL1 and CCDC8, leading to disordered ubiquitination, cause one of the commonest primordial growth disorders, 3-M syndrome. This condition is associated with (1) abnormal p53 function, (2) GH and/or IGF1 resistance, which may relate to failure to recycle signalling molecules, and (3) cellular IGF2 deficiency. However the exact molecular mechanisms that may link these abnormalities generating growth ... [more]
J. Mol. Endocrinol. Apr. 07, 2014; 0(0); [Pubmed: 24711643]
Throughput
- High Throughput
Curated By
- BioGRID