BAIT
NGFR
LNGFR, RNNGFRR, Tnfrsf16, p75, p75NTR
nerve growth factor receptor
GO Process (37)
GO Function (9)
GO Component (17)
Gene Ontology Biological Process
- axon guidance [ISO]
- cellular response to oxidative stress [IMP]
- central nervous system development [ISO]
- circadian regulation of gene expression [ISO, ISS]
- detection of temperature stimulus [ISO]
- glucose homeostasis [ISO, ISS]
- hair follicle morphogenesis [ISO]
- intracellular protein transport [ISO, ISS]
- negative regulation of cell death [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [ISO]
- negative regulation of hair follicle development [ISO]
- negative regulation of mitochondrial depolarization [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron projection development [IDA]
- nerve development [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rho protein signal transduction [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell death [IDA]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of myelination [IMP]
- positive regulation of neuron death [IDA]
- positive regulation of odontogenesis of dentin-containing tooth [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of synaptic transmission, cholinergic [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- programmed cell death [ISO]
- regulation of gene expression [ISO]
- regulation of glucose import in response to insulin stimulus [ISO, ISS]
- regulation of reactive oxygen species metabolic process [IMP]
- response to lipopolysaccharide [IEP]
- response to wounding [IMP]
- sensory perception of pain [IMP]
- signal transduction [IDA, ISO]
- skeletal muscle cell differentiation [IEP]
- skin development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cell [ISO]
- cell surface [ISO]
- clathrin-coated endocytic vesicle [IDA]
- coated vesicle [IDA]
- cytoplasm [IDA, ISO]
- dendrite membrane [IDA]
- external side of plasma membrane [IDA]
- intracellular [ISO]
- membrane raft [IDA]
- neuronal cell body membrane [IDA]
- neuronal postsynaptic density [ISO]
- nuclear envelope [IDA]
- nucleus [IDA]
- perikaryon [IDA]
- plasma membrane [IDA, ISO, TAS]
- rough endoplasmic reticulum [IDA]
Rattus norvegicus
PREY
PSEN1
presenilin 1
GO Process (85)
GO Function (7)
GO Component (35)
Gene Ontology Biological Process
- Cajal-Retzius cell differentiation [ISO]
- L-glutamate transport [ISO]
- Notch receptor processing [IBA, ISO]
- Notch signaling pathway [ISO]
- T cell activation involved in immune response [ISO]
- T cell receptor signaling pathway [ISO]
- activation of MAPKK activity [ISO]
- amyloid precursor protein catabolic process [IBA, ISO]
- autophagic vacuole assembly [ISO]
- autophagy [ISO]
- beta-amyloid formation [ISO]
- beta-amyloid metabolic process [IBA, ISO]
- blood vessel development [ISO]
- brain development [ISO]
- brain morphogenesis [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IBA]
- canonical Wnt signaling pathway [IBA]
- cell fate specification [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular protein metabolic process [ISO]
- cellular response to DNA damage stimulus [ISO]
- cerebral cortex cell migration [ISO]
- cerebral cortex development [ISO]
- choline transport [ISO]
- dorsal/ventral neural tube patterning [ISO]
- embryonic limb morphogenesis [ISO]
- endoplasmic reticulum calcium ion homeostasis [ISO]
- epithelial cell proliferation [ISO]
- eye photoreceptor cell development [NAS]
- forebrain development [ISO]
- heart development [ISO]
- heart looping [ISO]
- hematopoietic progenitor cell differentiation [ISO]
- learning or memory [ISO]
- locomotion [ISO]
- membrane protein ectodomain proteolysis [IMP, ISO, ISS]
- memory [ISO]
- mitochondrial transport [ISO]
- myeloid dendritic cell differentiation [ISO]
- myeloid leukocyte differentiation [ISO]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of apoptotic signaling pathway [ISO]
- negative regulation of axonogenesis [ISO]
- negative regulation of epidermal growth factor-activated receptor activity [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of ubiquitin-protein transferase activity [ISO]
- neurogenesis [ISO]
- neuron apoptotic process [ISO]
- neuron development [ISO]
- neuron differentiation [ISO]
- neuron migration [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of catalytic activity [ISO, ISS]
- positive regulation of coagulation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of receptor recycling [ISO]
- post-embryonic development [ISO]
- protein glycosylation [ISO]
- protein maturation [ISO]
- protein processing [IDA, ISO, ISS]
- protein transport [ISO]
- proteolysis [ISO]
- regulation of epidermal growth factor-activated receptor activity [ISO]
- regulation of phosphorylation [ISO]
- regulation of protein binding [ISO]
- regulation of resting membrane potential [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of synaptic transmission, glutamatergic [ISO]
- response to oxidative stress [ISO]
- segmentation [ISO]
- single organismal cell-cell adhesion [ISO]
- skeletal system morphogenesis [ISO]
- skin morphogenesis [ISO]
- smooth endoplasmic reticulum calcium ion homeostasis [IBA, ISO]
- somitogenesis [ISO]
- synaptic vesicle targeting [ISO]
- thymus development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO, ISS]
- Z disc [IBA]
- apical plasma membrane [IBA]
- axon [IBA, ISO]
- cell [ISO]
- cell cortex [IBA]
- cell surface [IDA]
- centrosome [ISO]
- ciliary rootlet [IBA, ISO]
- cytoplasmic vesicle [ISO]
- dendrite [ISO]
- dendritic shaft [IBA, ISO]
- endoplasmic reticulum [IBA, ISO, ISS]
- gamma-secretase complex [ISO]
- growth cone [IBA, ISO]
- integral component of plasma membrane [IBA, ISO, ISS]
- intracellular [ISO]
- kinetochore [ISO]
- lysosomal membrane [IDA]
- membrane [ISO]
- membrane raft [IDA, ISO]
- membrane-bounded organelle [ISO]
- mitochondrial inner membrane [IDA]
- mitochondrion [IDA, ISO, ISS]
- neuromuscular junction [IDA]
- neuron projection [IDA]
- neuronal cell body [IBA, ISO]
- nuclear membrane [ISO]
- nuclear outer membrane [ISO]
- nucleus [IBA, ISO]
- perinuclear region of cytoplasm [IBA]
- plasma membrane [ISO]
- protein complex [IDA]
- rough endoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [ISO]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation.
The present study shows that increased Abeta production in hippocampal neurons, due to a failure of NGF signal, induces an unexpected phosphorylation of tyrosine kinase receptor A (TrkA), followed by activation of the phospholipase C gamma (PLCgamma) pathway and neuronal death. Such phosphorylation seems causally connected with 2 kinases known be involved in amyloidogenesis, Src and CDK5, and associated with ... [more]
Proc. Natl. Acad. Sci. U.S.A. Jul. 07, 2009; 106(27);11358-63 [Pubmed: 19549834]
Throughput
- Low Throughput
Curated By
- BioGRID