PDGFRB
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- aorta morphogenesis [ISS]
- cardiac myofibril assembly [ISS]
- cell chemotaxis [IDA]
- cell migration [IMP]
- cell migration involved in coronary angiogenesis [ISS]
- cell migration involved in vasculogenesis [ISS]
- cellular response to platelet-derived growth factor stimulus [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- metanephric glomerular capillary formation [ISS]
- metanephric glomerular mesangial cell proliferation involved in metanephros development [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol metabolic process [IMP]
- phosphatidylinositol-mediated signaling [IMP, TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- platelet-derived growth factor receptor-beta signaling pathway [IMP]
- positive regulation of DNA biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of calcium ion import [ISS]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of chemotaxis [ISS]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [ISS]
- positive regulation of mitosis [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of reactive oxygen species metabolic process [ISS]
- positive regulation of smooth muscle cell migration [IMP, ISS]
- positive regulation of smooth muscle cell proliferation [IMP, ISS]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton organization [ISS]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- smooth muscle cell chemotaxis [ISS]
Gene Ontology Molecular Function- platelet activating factor receptor activity [TAS]
- platelet-derived growth factor beta-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- platelet-derived growth factor-activated receptor activity [TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor binding [IPI]
- vascular endothelial growth factor binding [IPI]
- platelet activating factor receptor activity [TAS]
- platelet-derived growth factor beta-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- platelet-derived growth factor-activated receptor activity [TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor binding [IPI]
- vascular endothelial growth factor binding [IPI]
Gene Ontology Cellular Component
PDGFB
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- activation of protein kinase B activity [IDA]
- activation of protein kinase activity [IDA]
- blood coagulation [TAS]
- cell chemotaxis [IDA]
- cellular response to growth factor stimulus [IDA]
- cellular response to mycophenolic acid [ISS]
- embryonic placenta development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- heart development [ISS]
- hemopoiesis [IMP]
- innate immune response [TAS]
- metanephric glomerular mesangial cell development [ISS]
- monocyte chemotaxis [IDA]
- negative regulation of phosphatidylinositol biosynthetic process [IDA]
- negative regulation of platelet activation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- paracrine signaling [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- positive chemotaxis [IDA]
- positive regulation of DNA biosynthetic process [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of calcium ion import [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of chemotaxis [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of glomerular mesangial cell proliferation [IDA]
- positive regulation of hyaluronan biosynthetic process [IDA]
- positive regulation of metanephric mesenchymal cell migration [IDA]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [IDA]
- positive regulation of mitosis [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- reactive oxygen species metabolic process [IMP]
- response to wounding [IDA, NAS]
- transforming growth factor beta receptor signaling pathway [ISS]
Gene Ontology Molecular Function- chemoattractant activity [IDA]
- collagen binding [IDA]
- growth factor activity [IDA]
- identical protein binding [IPI]
- platelet-derived growth factor binding [IPI]
- platelet-derived growth factor receptor binding [IDA, IPI, NAS]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- superoxide-generating NADPH oxidase activator activity [IDA]
- chemoattractant activity [IDA]
- collagen binding [IDA]
- growth factor activity [IDA]
- identical protein binding [IPI]
- platelet-derived growth factor binding [IPI]
- platelet-derived growth factor receptor binding [IDA, IPI, NAS]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- superoxide-generating NADPH oxidase activator activity [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells.
PDGF-dependent hepatic stellate cell (HSC) recruitment is an essential step in liver fibrosis and the sinusoidal vascular changes that accompany this process. However, the mechanisms that regulate PDGF signaling remain incompletely defined. Here, we found that in two rat models of liver fibrosis, the axonal guidance molecule neuropilin-1 (NRP-1) was upregulated in activated HSCs, which exhibit the highly motile myofibroblast ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PDGFRB PDGFB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PDGFB PDGFRB | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID