BAIT

ZNF451

COASTER, dJ417I1.1, RP3-417I1.1
zinc finger protein 451
GO Process (0)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens
PREY

PIAS2

ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4
protein inhibitor of activated STAT, 2
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator.

Karvonen U, Jaeaeskelaeinen T, Rytinki M, Kaikkonen S, Palvimo JJ

Covalent modification by small ubiquitin-related modifiers (SUMOs) is an important means to regulate dynamic residency of transcription factors within nuclear compartments. Here, we identify a multi-C(2)H(2)-type zinc finger protein (ZNF), ZNF451, as a novel nuclear protein that can be associated with promyelocytic leukemia bodies. In keeping with its interaction with SUMO E2 conjugase Ubc9 and SUMOs, ZNF451 is covalently modified ... [more]

J. Mol. Biol. Oct. 10, 2008; 382(3);585-600 [Pubmed: 18656483]

Throughput

  • Low Throughput

Additional Notes

  • mammalian two-hybrid

Curated By

  • BioGRID