BAIT
ZNF451
COASTER, dJ417I1.1, RP3-417I1.1
zinc finger protein 451
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
PIAS2
ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4
protein inhibitor of activated STAT, 2
GO Process (4)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator.
Covalent modification by small ubiquitin-related modifiers (SUMOs) is an important means to regulate dynamic residency of transcription factors within nuclear compartments. Here, we identify a multi-C(2)H(2)-type zinc finger protein (ZNF), ZNF451, as a novel nuclear protein that can be associated with promyelocytic leukemia bodies. In keeping with its interaction with SUMO E2 conjugase Ubc9 and SUMOs, ZNF451 is covalently modified ... [more]
J. Mol. Biol. Oct. 10, 2008; 382(3);585-600 [Pubmed: 18656483]
Throughput
- Low Throughput
Additional Notes
- mammalian two-hybrid
Curated By
- BioGRID