BAIT
EED
HEED, WAIT1
embryonic ectoderm development
GO Process (1)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TPR
translocated promoter region, nuclear basket protein
GO Process (37)
GO Function (12)
GO Component (13)
Gene Ontology Biological Process
- MAPK import into nucleus [IMP]
- RNA export from nucleus [IMP]
- RNA import into nucleus [IDA]
- carbohydrate metabolic process [TAS]
- cellular response to heat [IDA]
- cellular response to interferon-alpha [ISS]
- cytokine-mediated signaling pathway [TAS]
- glucose transport [TAS]
- hexose transport [TAS]
- mRNA export from nucleus in response to heat stress [IDA]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of RNA export from nucleus [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of translational initiation [IMP]
- nuclear matrix organization [IMP]
- nuclear pore complex assembly [IMP]
- nuclear pore organization [IMP]
- positive regulation of heterochromatin assembly [IMP]
- positive regulation of intracellular protein transport [IMP]
- positive regulation of mitotic cell cycle spindle assembly checkpoint [IMP]
- positive regulation of protein export from nucleus [ISS]
- positive regulation of protein import into nucleus [IMP]
- protein export from nucleus [IMP]
- protein import into nucleus [IDA, IMP]
- regulation of glucose transport [TAS]
- regulation of mRNA export from nucleus [IMP]
- regulation of mitotic sister chromatid separation [IMP]
- regulation of protein export from nucleus [IMP]
- regulation of protein import into nucleus [IMP]
- regulation of protein stability [IMP]
- regulation of spindle assembly involved in mitosis [IMP]
- response to epidermal growth factor [IDA]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- viral process [TAS]
Gene Ontology Molecular Function- chromatin binding [IDA]
- dynein complex binding [IDA]
- heat shock protein binding [IDA]
- mRNA binding [IDA]
- mitogen-activated protein kinase binding [IDA]
- nucleocytoplasmic transporter activity [IDA]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transporter activity [IMP]
- tubulin binding [IDA]
- chromatin binding [IDA]
- dynein complex binding [IDA]
- heat shock protein binding [IDA]
- mRNA binding [IDA]
- mitogen-activated protein kinase binding [IDA]
- nucleocytoplasmic transporter activity [IDA]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transporter activity [IMP]
- tubulin binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID