BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRKDC
AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip
protein kinase, DNA activated, catalytic polypeptide
GO Process (36)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- B cell lineage commitment [IMP]
- T cell differentiation in thymus [IMP]
- T cell lineage commitment [IMP]
- T cell receptor V(D)J recombination [IMP]
- V(D)J recombination [IGI]
- brain development [IGI]
- cellular response to insulin stimulus [ISO]
- double-strand break repair [IMP]
- double-strand break repair via homologous recombination [IBA]
- double-strand break repair via nonhomologous end joining [IMP]
- ectopic germ cell programmed cell death [IMP]
- heart development [IGI]
- immunoglobulin V(D)J recombination [IMP]
- immunoglobulin production [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- lymphocyte differentiation [IMP]
- negative regulation of cellular senescence [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of response to gamma radiation [ISO]
- peptidyl-serine phosphorylation [ISO]
- phosphorylation [IBA]
- positive regulation of apoptotic process [IMP]
- positive regulation of developmental growth [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of immune system process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- pro-B cell differentiation [IMP]
- protein destabilization [IDA]
- protein phosphorylation [IDA]
- regulation of circadian rhythm [IMP]
- response to gamma radiation [IMP]
- signal transduction involved in mitotic G1 DNA damage checkpoint [ISO]
- somitogenesis [IGI]
- spleen development [ISO]
- telomere maintenance [IMP]
- thymus development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID