BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAC1
AL023026, D5Ertd559e
RAS-related C3 botulinum substrate 1
GO Process (51)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IGI]
- GTP catabolic process [IDA, ISO]
- Wnt signaling pathway, planar cell polarity pathway [IGI]
- actin cytoskeleton organization [ISO]
- actin filament organization [ISO]
- actin filament polymerization [IDA]
- anatomical structure arrangement [IMP]
- auditory receptor cell morphogenesis [IMP]
- axon guidance [IMP]
- bone resorption [ISO]
- cell adhesion [IDA]
- cell migration [IDA]
- cell motility [ISO]
- cell proliferation [ISO]
- cell-cell junction organization [IMP]
- cellular component movement [ISO]
- cerebral cortex radially oriented cell migration [IMP]
- chemotaxis [ISO]
- cochlea morphogenesis [IMP]
- cytoskeleton organization [IDA]
- dendrite development [IDA]
- dendrite morphogenesis [IGI]
- dopaminergic neuron differentiation [IGI]
- embryonic olfactory bulb interneuron precursor migration [IMP]
- endocytosis [IDA]
- engulfment of apoptotic cell [IDA]
- epithelial cell morphogenesis [IMP]
- hyperosmotic response [IDA]
- lamellipodium assembly [IDA, ISO, TAS]
- localization within membrane [ISO]
- mast cell chemotaxis [ISO]
- negative regulation of interleukin-23 production [ISO]
- phagocytosis, engulfment [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neutrophil chemotaxis [IMP, ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein localization to plasma membrane [IDA]
- regulation of cell migration [IMP, ISO]
- regulation of respiratory burst [ISO]
- ruffle assembly [IMP]
- ruffle organization [ISO]
- semaphorin-plexin signaling pathway [ISO]
- small GTPase mediated signal transduction [IDA]
- substrate adhesion-dependent cell spreading [IDA, IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [ISO]
- actin filament [ISO]
- cell projection [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [IDA]
- focal adhesion [ISO]
- lamellipodium [IDA, ISO]
- membrane [IDA, ISO]
- phagocytic cup [IDA]
- ruffle membrane [IDA]
- trans-Golgi network [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID