BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PFN1
Pfn, DN-183N8.15-001
profilin 1
GO Process (15)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- negative regulation of actin filament bundle assembly [ISO]
- negative regulation of actin filament polymerization [ISO]
- negative regulation of stress fiber assembly [ISO]
- neural tube closure [IGI]
- positive regulation of ATPase activity [ISO]
- positive regulation of DNA metabolic process [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of ruffle assembly [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of viral transcription [ISO]
- regulation of actin polymerization or depolymerization [TAS]
- regulation of transcription from RNA polymerase II promoter [IGI]
- sequestering of actin monomers [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID