BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAB7
Rab7a
RAB7, member RAS oncogene family
GO Process (14)
GO Function (5)
GO Component (15)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- bone resorption [ISO]
- early endosome to late endosome transport [ISO]
- endosome to lysosome transport [IBA, ISO]
- epidermal growth factor catabolic process [ISO]
- intracellular protein transport [TAS]
- phagosome acidification [ISO]
- phagosome-lysosome fusion [IBA, ISO]
- positive regulation of exosomal secretion [ISO]
- protein targeting to lysosome [ISO]
- protein to membrane docking [ISO]
- regulation of autophagic vacuole assembly [ISO]
- retrograde transport, endosome to Golgi [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- alveolar lamellar body [ISO]
- cell [TAS]
- cytoplasm [IDA]
- cytoplasmic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [TAS]
- intracellular membrane-bounded organelle [ISO]
- late endosome [IDA, ISO]
- lysosome [IBA, ISO]
- phagocytic vesicle [IBA, ISO]
- pre-autophagosomal structure membrane [IDA]
- retromer complex [ISO]
- terminal bouton [ISO]
- vacuolar membrane [IBA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID