BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TPM1
AA986836, AI854628, TM2, Tm3, Tmpa, Tpm-1, alpha-TM
tropomyosin 1, alpha
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- actin filament capping [ISO]
- cardiac muscle contraction [IMP, ISO]
- embryo development [IMP]
- in utero embryonic development [IMP]
- muscle filament sliding [ISO]
- negative regulation of cell migration [ISO]
- positive regulation of ATPase activity [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of heart rate by epinephrine [IMP]
- positive regulation of stress fiber assembly [ISO]
- regulation of ATPase activity [ISO]
- ruffle organization [ISO]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- wound healing [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID