BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
VIM
RP23-185P20.1
vimentin
GO Process (11)
GO Function (12)
GO Component (16)
Gene Ontology Biological Process
- Bergmann glial cell differentiation [IMP]
- SMAD protein signal transduction [IDA]
- astrocyte development [IGI]
- intermediate filament organization [IGI]
- intermediate filament-based process [IMP]
- lens fiber cell development [IDA]
- negative regulation of neuron projection development [IGI]
- positive regulation of gene expression [IMP]
- positive regulation of glial cell proliferation [ISO]
- regulation of Schwann cell migration [ISO]
- regulation of axonogenesis [ISO]
Gene Ontology Molecular Function- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO]
- structural constituent of eye lens [IDA]
- structural molecule activity [IMP]
- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO]
- structural constituent of eye lens [IDA]
- structural molecule activity [IMP]
Gene Ontology Cellular Component
- axon [ISO]
- cell body [ISO]
- cell leading edge [IDA]
- cell projection [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytoskeleton [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intermediate filament [IDA, ISO]
- intermediate filament cytoskeleton [ISO]
- neuron projection [IDA]
- perinuclear region of cytoplasm [ISO]
- peroxisome [ISO]
- plasma membrane [IDA, ISO]
- type III intermediate filament [TAS]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID