BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BRAF
9930012E13Rik, AA120551, AA387315, AA473386, B-raf, Braf-2, Braf2, C230098H17, C87398, D6Ertd631e
Braf transforming gene
GO Process (27)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- CD4-positive, alpha-beta T cell differentiation [IMP]
- MAPK cascade [ISO]
- activation of MAPKK activity [ISO]
- alpha-beta T cell differentiation [IMP]
- cell differentiation [IGI]
- cellular response to calcium ion [ISO]
- cellular response to drug [IDA]
- long-term synaptic potentiation [IMP]
- myeloid progenitor cell differentiation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of fibroblast migration [IMP]
- negative regulation of neuron apoptotic process [IMP, ISO]
- negative regulation of synaptic vesicle exocytosis [IMP]
- positive T cell selection [IMP]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP, ISO]
- positive regulation of gene expression [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of stress fiber assembly [IGI, IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IMP]
- protein heterooligomerization [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of cell proliferation [IGI]
- response to cAMP [ISO]
- response to peptide hormone [ISO]
- somatic stem cell maintenance [IGI]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID