BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GSTP1
GstpiB
glutathione S-transferase, pi 1
GO Process (22)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [IDA]
- common myeloid progenitor cell proliferation [IMP]
- glutathione metabolic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of JUN kinase activity [IDA, IMP]
- negative regulation of acute inflammatory response [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of biosynthetic process [IDA]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of leukocyte proliferation [IMP]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of neutrophil aggregation [NAS]
- negative regulation of nitric-oxide synthase biosynthetic process [IDA]
- negative regulation of peroxidase activity [IDA]
- negative regulation of stress-activated MAPK cascade [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- positive regulation of superoxide anion generation [IMP]
- regulation of ERK1 and ERK2 cascade [IDA]
- regulation of stress-activated MAPK cascade [IDA]
- response to reactive oxygen species [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID