BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BAG6
2410045D21Rik, AA408914, BAG-6, Bat3, D17H6S52E, G3, Scythe
BCL2-associated athanogene 6
GO Process (17)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- brain development [IMP]
- embryo development [IMP]
- internal peptidyl-lysine acetylation [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- kidney development [IMP]
- lung development [IMP]
- negative regulation of apoptotic process [IGI]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of proteolysis [IMP]
- protein stabilization [IMP]
- regulation of apoptotic process [IMP]
- spermatogenesis [IMP]
- synaptonemal complex assembly [IMP]
- tail-anchored membrane protein insertion into ER membrane [ISO]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID