BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MAP2K3
AW212142, MEK3, MKK3, Prkmk3, mMKK3b, RP23-467E19.1
mitogen-activated protein kinase kinase 3
GO Process (10)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- MAPK cascade [IDA, IMP]
- activation of MAPK activity [IDA, IMP]
- cardiac muscle contraction [IMP]
- inflammatory response [IMP]
- intracellular signal transduction [IBA]
- positive regulation of protein kinase activity [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein phosphorylation [IMP]
- regulation of cytokine biosynthetic process [IMP]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID