BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GNAI2
C76432, Galphai2, Gia, Gnai-2
guanine nucleotide binding protein (G protein), alpha inhibiting 2
GO Process (14)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [IMP]
- G-protein coupled receptor signaling pathway [ISO]
- GTP catabolic process [IBA]
- activation of MAPKK activity [ISO]
- adenosine receptor signaling pathway [IBA, ISO]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [IMP, ISA]
- cell division [ISO]
- cell proliferation [IPI]
- gamma-aminobutyric acid signaling pathway [IBA, ISO]
- intracellular signal transduction [ISO]
- negative regulation of synaptic transmission [ISO]
- positive regulation of cell proliferation [ISO]
- regulation of calcium ion transport [ISO]
- regulation of heart contraction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID