BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DSP
2300002E22Rik, 5730453H04Rik, AA407887, AA407888, AW109828, DP
desmoplakin
GO Process (13)
GO Function (6)
GO Component (12)
Gene Ontology Biological Process
- adherens junction organization [IMP]
- bundle of His cell to Purkinje myocyte communication [ISO]
- desmosome organization [IMP]
- intermediate filament cytoskeleton organization [IMP]
- intermediate filament organization [IMP]
- keratinocyte differentiation [ISO]
- peptide cross-linking [ISO]
- protein localization to adherens junction [IMP]
- regulation of heart rate by cardiac conduction [ISO]
- single organismal cell-cell adhesion [IMP]
- skin development [IMP]
- ventricular cardiac muscle cell action potential [ISO]
- ventricular compact myocardium morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID