BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSPH1
105kDa, AI790491, Hsp105, Hsp110, hsp-E7I
heat shock 105kDa/110kDa protein 1
GO Process (11)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- chaperone mediated protein folding requiring cofactor [IDA]
- establishment of protein localization to mitochondrion [IMP]
- intrinsic apoptotic signaling pathway in response to hydrogen peroxide [IMP]
- negative regulation of apoptotic signaling pathway [IMP]
- negative regulation of neuron apoptotic process [TAS]
- positive regulation of MHC class I biosynthetic process [TAS]
- positive regulation of NK T cell activation [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of microtubule cytoskeleton organization [NAS]
- regulation of p38MAPK cascade [IGI]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID