BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
EHD1
AA409636, Past1, RME-1
EH-domain containing 1
GO Process (12)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- cellular response to nerve growth factor stimulus [ISO]
- cholesterol homeostasis [IMP]
- endocytic recycling [ISO]
- endocytosis [IDA, ISO]
- endosomal transport [IDA]
- intracellular protein transport [ISO]
- low-density lipoprotein particle clearance [IMP]
- neuron projection development [ISO]
- positive regulation of cholesterol storage [IMP]
- positive regulation of endocytic recycling [IMP]
- positive regulation of myoblast fusion [IMP]
- protein homooligomerization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- early endosome [IDA]
- early endosome membrane [ISO]
- endocytic vesicle [IDA]
- endosome [IDA]
- endosome membrane [ISO]
- extracellular vesicular exosome [ISO]
- lipid particle [IDA]
- membrane [ISO]
- myelin sheath [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet dense tubular network membrane [IDA]
- recycling endosome membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID