BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CTNNA1
2010010M04Rik, AA517462, AI988031, Catna1
catenin (cadherin associated protein), alpha 1
GO Process (15)
GO Function (7)
GO Component (11)
Gene Ontology Biological Process
- apical junction assembly [IMP]
- cellular protein localization [IMP]
- cellular response to indole-3-methanol [ISO]
- epithelial cell-cell adhesion [IMP]
- establishment or maintenance of cell polarity [IMP]
- gap junction assembly [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell motility [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of integrin-mediated signaling pathway [IMP]
- negative regulation of neuroblast proliferation [IGI, IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- positive regulation of smoothened signaling pathway [IGI]
- protein heterooligomerization [ISO]
- regulation of cell proliferation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID