BAIT
EED
ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk
embryonic ectoderm development
GO Process (4)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DAPK1
D13Ucla1, DAP-Kinase
death associated protein kinase 1
GO Process (12)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- apoptotic process [ISO]
- apoptotic signaling pathway [ISO, TAS]
- cellular response to interferon-gamma [IMP, ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI, IMP]
- intracellular signal transduction [IDA, ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of translation [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, IDA, ISO]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The central role of EED in the orchestration of polycomb group complexes.
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. ... [more]
Nat Commun Jan. 24, 2014; 5(0);3127 [Pubmed: 24457600]
Throughput
- High Throughput
Curated By
- BioGRID