BAIT
AGO2
1110029L17Rik, 2310051F07Rik, AI225898, AL022874, AW546247, ENSMUSG00000072493, Eif2c2, Gerp95, Gm10365, mKIAA4215
argonaute RISC catalytic subunit 2
GO Process (12)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA, ISO]
- gene silencing by RNA [IMP]
- mRNA cleavage [IMP]
- mRNA cleavage involved in gene silencing by miRNA [ISO]
- miRNA metabolic process [IDA]
- negative regulation of translation involved in gene silencing by miRNA [ISO]
- negative regulation of translational initiation [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IMP]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [IMP]
- post-embryonic development [IMP]
- pre-miRNA processing [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CDKN1B
AA408329, AI843786, Kip1, p27, p27Kip1
cyclin-dependent kinase inhibitor 1B
GO Process (26)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA, ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- autophagic cell death [ISO]
- cell cycle arrest [IDA, ISO]
- cell death [ISO]
- cellular response to antibiotic [IDA]
- cellular response to lithium ion [ISO]
- cellular response to organic cyclic compound [IDA]
- inner ear development [IMP]
- mitotic cell cycle arrest [ISO]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cellular component movement [IDA]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- negative regulation of kinase activity [ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of phosphorylation [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of cell death [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of microtubule polymerization [IGI]
- potassium ion transport [IGI]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
ELAVL1 Modulates Transcriptome-wide miRNA Binding in Murine Macrophages.
Posttranscriptional gene regulation by miRNAs and RNA binding proteins (RBP) is important in development, physiology, and disease. To examine the interplay between miRNAs and the RBP ELAVL1 (HuR), we mapped miRNA binding sites at the transcriptome-wide scale in wild-type and Elavl1 knockout murine bone-marrow-derived macrophages. Proximity of ELAVL1 binding sites attenuated miRNA binding to transcripts and promoted gene expression. Transcripts ... [more]
Cell Rep Dec. 24, 2014; 9(6);2330-43 [Pubmed: 25533351]
Throughput
- Low Throughput
Additional Notes
- Figure 3E
Curated By
- BioGRID