BAIT

EGFR

ERBB, ERBB1, HER1, NISBD2, PIG61, mENA
epidermal growth factor receptor
GO Process (42)
GO Function (15)
GO Component (13)

Gene Ontology Biological Process

Homo sapiens
PREY

EHD4

PAST4, FKSG7
EH-domain containing 4
GO Process (2)
GO Function (2)
GO Component (5)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Proteomic analysis of the EGFR interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.

Tong J, Taylor P, Moran MF

Aberrant expression, activation, and stabilization of epidermal growth factor receptor (EGFR) is causally associated with several human cancers. Post-translational modifications and protein-protein interactions directly modulate the signaling and trafficking of the EGFR. Activated EGFR is internalized by endocytosis and then either recycled back to the cell surface or degraded in the lysosome. EGFR internalization and recycling also occur in response ... [more]

Mol. Cell Proteomics May. 05, 2014; 0(0); [Pubmed: 24797263]

Throughput

  • High Throughput

Curated By

  • BioGRID