BAIT

ERLIN2

C8orf2, Erlin-2, NET32, SPFH2, SPG18, UNQ2441

ER lipid raft associated 2

Alzheimer's Disease Project

GO Process (1)

GO Function (1)

GO Component (6)

Gene Ontology Biological Process

ER-associated ubiquitin-dependent protein catabolic process [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

endoplasmic reticulum [IDA]

endoplasmic reticulum membrane [IDA]

extracellular vesicular exosome [IDA]

plasma membrane [IDA]

protein complex [IDA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

DUSP3

VHR

dual specificity phosphatase 3

GO Process (23)

GO Function (3)

GO Component (6)

Gene Ontology Biological Process

MyD88-dependent toll-like receptor signaling pathway [TAS]

MyD88-independent toll-like receptor signaling pathway [TAS]

TRIF-dependent toll-like receptor signaling pathway [TAS]

inactivation of MAPK activity [IMP]

innate immune response [TAS]

negative regulation of ERK1 and ERK2 cascade [IDA]

negative regulation of JNK cascade [IDA, IMP]

negative regulation of MAPK cascade [IMP]

negative regulation of T cell activation [IDA]

negative regulation of T cell receptor signaling pathway [IDA]

neurotrophin TRK receptor signaling pathway [TAS]

peptidyl-tyrosine dephosphorylation [IDA]

positive regulation of mitotic cell cycle [IMP]

stress-activated MAPK cascade [TAS]

toll-like receptor 10 signaling pathway [TAS]

toll-like receptor 2 signaling pathway [TAS]

toll-like receptor 3 signaling pathway [TAS]

toll-like receptor 4 signaling pathway [TAS]

toll-like receptor 5 signaling pathway [TAS]

toll-like receptor 9 signaling pathway [TAS]

toll-like receptor TLR1:TLR2 signaling pathway [TAS]

toll-like receptor TLR6:TLR2 signaling pathway [TAS]

toll-like receptor signaling pathway [TAS]

Gene Ontology Molecular Function

MAP kinase phosphatase activity [IMP]
protein tyrosine phosphatase activity [IDA]
protein tyrosine/serine/threonine phosphatase activity [IDA, IMP]

Gene Ontology Cellular Component

cytoplasm [IDA]

extracellular vesicular exosome [IDA]

immunological synapse [IDA]

nucleoplasm [IDA, TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Defining human ERAD networks through an integrative mapping strategy.

Christianson JC, Olzmann JA, Shaler TA, Sowa ME, Bennett EJ, Richter CM, Tyler RE, Greenblatt EJ, Harper JW, Kopito RR

Proteins that fail to correctly fold or assemble into oligomeric complexes in the endoplasmic reticulum (ER) are degraded by a ubiquitin- and proteasome-dependent process known as ER-associated degradation (ERAD). Although many individual components of the ERAD system have been identified, how these proteins are organized into a functional network that coordinates recognition, ubiquitylation and dislocation of substrates across the ER ... [more]

Nat. Cell Biol. Jan. 01, 2012; 14(1);93-105 [Pubmed: 22119785]

Throughput

High Throughput

Additional Notes

in the presence of digitonin

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
DUSP3 ERLIN2	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Huttlin EL (2021)	High	0.969	BioGRID	3108160

Curated By

BioGRID