BAIT
FAF2
ETEA, UBXD8, UBXN3B
Fas associated factor family member 2
GO Process (2)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VAPB
ALS8, VAMP-B, VAP-B, RP5-1018E9.1
VAMP (vesicle-associated membrane protein)-associated protein B and C
GO Process (16)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- COPII-coated vesicle budding [IMP]
- ER to Golgi vesicle-mediated transport [IMP]
- activation of signaling protein activity involved in unfolded protein response [IDA]
- cellular calcium ion homeostasis [IMP]
- endoplasmic reticulum organization [IMP]
- endoplasmic reticulum unfolded protein response [IMP]
- modulation by virus of host morphology or physiology [IDA]
- negative regulation by host of viral genome replication [IDA]
- negative regulation by host of viral release from host cell [IDA]
- negative regulation by virus of viral protein levels in host cell [IDA]
- positive regulation by host of viral genome replication [IDA]
- positive regulation by host of viral release from host cell [IDA]
- positive regulation of viral genome replication [IMP]
- small molecule metabolic process [TAS]
- sphingolipid biosynthetic process [TAS]
- sphingolipid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Defining human ERAD networks through an integrative mapping strategy.
Proteins that fail to correctly fold or assemble into oligomeric complexes in the endoplasmic reticulum (ER) are degraded by a ubiquitin- and proteasome-dependent process known as ER-associated degradation (ERAD). Although many individual components of the ERAD system have been identified, how these proteins are organized into a functional network that coordinates recognition, ubiquitylation and dislocation of substrates across the ER ... [more]
Nat. Cell Biol. Jan. 01, 2012; 14(1);93-105 [Pubmed: 22119785]
Throughput
- High Throughput
Additional Notes
- in the presence of digitonin
Curated By
- BioGRID