BAIT
EMC1
KIAA0090, PSEC0263
ER membrane protein complex subunit 1
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Homo sapiens
PREY
VDAC2
POR, RP11-375G3.1
voltage-dependent anion channel 2
GO Process (0)
GO Function (2)
GO Component (4)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Defining human ERAD networks through an integrative mapping strategy.
Proteins that fail to correctly fold or assemble into oligomeric complexes in the endoplasmic reticulum (ER) are degraded by a ubiquitin- and proteasome-dependent process known as ER-associated degradation (ERAD). Although many individual components of the ERAD system have been identified, how these proteins are organized into a functional network that coordinates recognition, ubiquitylation and dislocation of substrates across the ER ... [more]
Nat. Cell Biol. Jan. 01, 2012; 14(1);93-105 [Pubmed: 22119785]
Throughput
- High Throughput
Additional Notes
- in the presence of TX100
Curated By
- BioGRID