UBE2I
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
THRA
Gene Ontology Biological Process
- gene expression [TAS]
- hormone-mediated signaling pathway [IDA]
- negative regulation of DNA-templated transcription, initiation [IDA]
- negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- TBP-class protein binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone binding [IDA, IPI]
- thyroid hormone receptor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- TBP-class protein binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- thyroid hormone binding [IDA, IPI]
- thyroid hormone receptor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Biochemical Activity (Sumoylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Thyroid hormone receptor isoform-specific modification by SUMO modulates thyroid hormone-dependent gene regulation.
Thyroid hormone receptor (TR) α and β mediate thyroid hormone action at target tissues. TR isoforms have specific roles in development and in adult tissues. The mechanisms underlying TR isoform-specific action, however, are not well understood. We demonstrate that posttranslational modification of TR by conjugation of small ubiquitin-like modifier (SUMO) to TRα and TRβ plays an important role in triiodothyronine ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 1A
Curated By
- BioGRID