Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes.

Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K

Tom1 (target of Myb1) is a protein of unknown function. Tom1 and its relative Tom1L1 have an N-terminal VHS (Vps27p/Hrs/Stam) domain followed by a GAT (GGA and Tom1) domain, both of which are also found in the GGA (Golgi-localizing, gamma-adaptin ear domain homology, ADP-ribosylation factor-binding protein) family of proteins. Although the VHS and GAT domains of GGA proteins bind to ... [more]

J. Biol. Chem. Jun. 04, 2004; 279(23);24435-43 [Pubmed: 15047686]

Throughput

  • Low Throughput

Additional Notes

  • Figure 3A

Curated By

  • BioGRID