BAIT

PLXNA1

NOV, NOVP, PLEXIN-A1, PLXN1
plexin A1
GO Process (2)
GO Function (2)
GO Component (5)
Homo sapiens
PREY

AKT1

AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1
GO Process (73)
GO Function (12)
GO Component (6)

Gene Ontology Biological Process

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The activity of the plexin-A1 receptor is regulated by Rac.

Turner LJ, Nicholls S, Hall A

Plexins constitute a large family of transmembrane proteins that act as receptors for the semaphorin family of ligands. They are best known for their role in growth cone guidance, although they also are widely expressed outside the nervous system. Plexins are thought to control axon guidance by modifying the growth cone cytoskeleton, and Rho GTPases have been strongly implicated in ... [more]

J. Biol. Chem. Aug. 06, 2004; 279(32);33199-205 [Pubmed: 15187088]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
PLXNA1 AKT1
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Low-BioGRID
-

Curated By

  • BioGRID