UBE2I
Gene Ontology Biological Process
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein sumoylation [IBA, ISO]
- protein ubiquitination [IBA, ISO]
- regulation of receptor activity [ISO]
Gene Ontology Molecular Function- HLH domain binding [IPI]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IBA, ISO]
- bHLH transcription factor binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- HLH domain binding [IPI]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IBA, ISO]
- bHLH transcription factor binding [ISO]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin-protein transferase activity [ISO]
GATA1
Gene Ontology Biological Process
- cell development [IMP]
- cell-cell signaling [IMP]
- cellular response to thyroid hormone stimulus [ISO]
- dendritic cell differentiation [IDA]
- embryonic hemopoiesis [IMP]
- eosinophil fate commitment [ISO]
- erythrocyte development [ISO]
- erythrocyte differentiation [IDA, IGI, IMP]
- in utero embryonic development [IMP]
- male gonad development [ISO]
- megakaryocyte differentiation [IDA, IGI, IMP, ISO]
- myeloid cell differentiation [IMP]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone mineralization [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transcription regulatory region DNA binding [ISO]
- platelet aggregation [IMP, ISO]
- platelet formation [IMP, ISO]
- positive regulation of erythrocyte differentiation [ISO]
- positive regulation of osteoblast proliferation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- regulation of definitive erythrocyte differentiation [IDA, ISO]
- regulation of glycoprotein biosynthetic process [IMP, ISO]
- transcription from RNA polymerase II promoter [IDA, ISO]
- transcriptional activation by promoter-enhancer looping [IDA]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA, ISO]
- DNA binding, bending [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding [IPI, ISO]
- chromatin DNA binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- p53 binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA, ISO]
- DNA binding, bending [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding [IPI, ISO]
- chromatin DNA binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- p53 binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
Gene Ontology Cellular Component
Biochemical Activity (Sumoylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Modification of the erythroid transcription factor GATA-1 by SUMO-1.
The activity of transcription factors is tightly modulated by posttranslational modifications affecting stability, localization, and protein-protein interactions. Conjugation to SUMO is a reversible posttranslational modification that has been shown to regulate important transcription factors involved in cell proliferation, differentiation, and tumor suppression. Here, we demonstrate that the erythroid transcription factor GATA-1 is sumoylated in vitro and in vivo and map ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 2A
- using SUMO1
Curated By
- BioGRID