BAIT

SUMO3

SMT3A, SMT3H1, SUMO-3, Smt3B

small ubiquitin-like modifier 3

GO Process (3)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

post-translational protein modification [TAS]

protein sumoylation [IDA, TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

extracellular vesicular exosome [IDA]

kinetochore [TAS]

nucleoplasm [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

HIPK2

PRO0593

homeodomain interacting protein kinase 2

GO Process (21)

GO Function (8)

GO Component (4)

Gene Ontology Biological Process

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IDA]

PML body organization [TAS]

SMAD protein signal transduction [IDA]

cellular response to hypoxia [TAS]

erythrocyte differentiation [ISS]

eye development [ISS]

intrinsic apoptotic signaling pathway [NAS]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [TAS]

modulation by virus of host morphology or physiology [NAS]

negative regulation of BMP signaling pathway [IMP]

peptidyl-serine phosphorylation [ISS]

peptidyl-threonine phosphorylation [ISS]

positive regulation of JNK cascade [IMP]

positive regulation of angiogenesis [IDA]

positive regulation of protein binding [ISS]

positive regulation of sequence-specific DNA binding transcription factor activity [ISS]

positive regulation of transcription from RNA polymerase II promoter [ISS]

positive regulation of transcription, DNA-templated [IMP]

positive regulation of transforming growth factor beta receptor signaling pathway [IMP]

protein phosphorylation [IDA]

regulation of cell cycle [TAS]

Gene Ontology Molecular Function

RNA polymerase II activating transcription factor binding [ISS]
RNA polymerase II transcription coactivator activity [ISS]
SMAD binding [IPI]
protein binding [IPI]
protein kinase activity [IDA]
protein serine/threonine kinase activity [ISS]
transcription corepressor activity [IDA]
virion binding [IPI]

Gene Ontology Cellular Component

cytoplasm [ISS]

nuclear body [IDA, TAS]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Publication

Control of nuclear HIPK2 localization and function by a SUMO interaction motif.

de la Vega L, Froebius K, Moreno R, Calzado MA, Geng H, Schmitz ML

The serine/threonine kinase HIPK2 regulates gene expression programs controlling differentiation and cell death. HIPK2 localizes in subnuclear speckles, but the structural components allowing this localization are not understood. A point mutation analysis allowed mapping two nuclear localization signals and a SUMO interaction motif (SIM) that also occurs in HIPK1 and HIPK3. The SIM binds all three major isoforms of SUMO ... [more]

Biochim. Biophys. Acta Feb. 01, 2011; 1813(2);283-97 [Pubmed: 21145359]

Throughput

Low Throughput

Additional Notes

#LPPI
Likely protein-protein interaction
figure 2.

Curated By

BioGRID