SUMO2
Gene Ontology Biological Process
Gene Ontology Molecular Function
MSH2
Gene Ontology Biological Process
- ATP catabolic process [IBA, IDA]
- B cell differentiation [ISS]
- B cell mediated immunity [ISS]
- DNA repair [IDA]
- double-strand break repair [IBA]
- intra-S DNA damage checkpoint [IBA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA]
- isotype switching [IBA, ISS]
- maintenance of DNA repeat elements [IMP]
- male gonad development [ISS]
- meiotic gene conversion [IBA]
- meiotic mismatch repair [IBA]
- mismatch repair [IDA, IGI]
- negative regulation of DNA recombination [IDA, ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of reciprocal meiotic recombination [IBA]
- positive regulation of helicase activity [IDA]
- postreplication repair [IDA]
- response to UV-B [IBA, ISS]
- response to X-ray [IBA, ISS]
- somatic hypermutation of immunoglobulin genes [IBA]
- somatic recombination of immunoglobulin gene segments [ISS]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- Y-form DNA binding [IBA]
- dinucleotide insertion or deletion binding [IDA]
- dinucleotide repeat insertion binding [IDA]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA, IMP]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
- single-stranded DNA binding [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- DNA binding [IDA]
- DNA-dependent ATPase activity [IBA]
- MutLalpha complex binding [IDA]
- Y-form DNA binding [IBA]
- dinucleotide insertion or deletion binding [IDA]
- dinucleotide repeat insertion binding [IDA]
- double-strand/single-strand DNA junction binding [IBA]
- double-stranded DNA binding [IDA]
- enzyme binding [IPI]
- four-way junction DNA binding [IDA]
- guanine/thymine mispair binding [IDA, IMP]
- heteroduplex DNA loop binding [IBA]
- magnesium ion binding [IDA]
- mismatched DNA binding [IDA]
- oxidized purine DNA binding [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- single guanine insertion binding [IDA]
- single thymine insertion binding [IDA]
- single-stranded DNA binding [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
Posttranslational modification of transcription factors by the small ubiquitin-related modifier SUMO is associated with transcriptional repression, but the underlying mechanisms remain incompletely described. We have identified binding of the LSD1/CoREST1/HDAC corepressor complex to SUMO-2. Here we show that CoREST1 binds directly and noncovalently to SUMO-2, but not SUMO-1, and CoREST1 bridges binding of the histone demethylase LSD1 to SUMO-2. Depletion ... [more]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SUMO2 MSH2 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | High | - | BioGRID | 2878296 | |
| SUMO2 MSH2 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 1508314 |
Curated By
- BioGRID