SUMO2
Gene Ontology Biological Process
Gene Ontology Molecular Function
PHF8
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- brain development [ISS]
- histone H3-K27 demethylation [IDA]
- histone H3-K36 demethylation [IDA]
- histone H3-K9 demethylation [IDA]
- histone H4-K20 demethylation [IDA]
- mitotic cell cycle [TAS]
- negative regulation of chromatin silencing at rDNA [IDA]
- positive regulation of transcription from RNA polymerase I promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
Gene Ontology Molecular Function- chromatin binding [IDA]
- histone demethylase activity [IDA]
- histone demethylase activity (H3-K27 specific) [IDA]
- histone demethylase activity (H3-K36 specific) [IDA]
- histone demethylase activity (H3-K9 specific) [IDA]
- histone demethylase activity (H4-K20 specific) [IDA]
- iron ion binding [IDA]
- methylated histone binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- protein binding [IPI]
- zinc ion binding [IDA]
- chromatin binding [IDA]
- histone demethylase activity [IDA]
- histone demethylase activity (H3-K27 specific) [IDA]
- histone demethylase activity (H3-K36 specific) [IDA]
- histone demethylase activity (H3-K9 specific) [IDA]
- histone demethylase activity (H4-K20 specific) [IDA]
- iron ion binding [IDA]
- methylated histone binding [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IDA]
- protein binding [IPI]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
Posttranslational modification of transcription factors by the small ubiquitin-related modifier SUMO is associated with transcriptional repression, but the underlying mechanisms remain incompletely described. We have identified binding of the LSD1/CoREST1/HDAC corepressor complex to SUMO-2. Here we show that CoREST1 binds directly and noncovalently to SUMO-2, but not SUMO-1, and CoREST1 bridges binding of the histone demethylase LSD1 to SUMO-2. Depletion ... [more]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Curated By
- BioGRID