BAIT
SUMO2
HSMT3, SMT3B, SMT3H2, SUMO3, Smt3A
small ubiquitin-like modifier 2
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
ZNF451
COASTER, dJ417I1.1, RP3-417I1.1
zinc finger protein 451
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
Posttranslational modification of transcription factors by the small ubiquitin-related modifier SUMO is associated with transcriptional repression, but the underlying mechanisms remain incompletely described. We have identified binding of the LSD1/CoREST1/HDAC corepressor complex to SUMO-2. Here we show that CoREST1 binds directly and noncovalently to SUMO-2, but not SUMO-1, and CoREST1 bridges binding of the histone demethylase LSD1 to SUMO-2. Depletion ... [more]
Mol. Cell Apr. 24, 2009; 34(2);145-54 [Pubmed: 19394292]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Curated By
- BioGRID