SEMA4A
Gene Ontology Biological Process
RAB11A
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Rab protein signal transduction [IBA]
- astral microtubule organization [ISO]
- cytokinesis [ISO]
- establishment of protein localization to membrane [ISO]
- establishment of protein localization to organelle [ISO]
- establishment of vesicle localization [ISO]
- exocytosis [IBA]
- exosomal secretion [ISO]
- intracellular protein transport [IBA]
- melanosome transport [IMP]
- mitotic metaphase plate congression [ISO]
- multivesicular body assembly [ISO]
- neuron projection development [ISO]
- positive regulation of G2/M transition of mitotic cell cycle [ISO]
- positive regulation of axon extension [IMP]
- positive regulation of epithelial cell migration [ISO]
- protein localization to plasma membrane [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of multivesicular body size [ISO]
- regulation of protein transport [ISO]
- regulation of vesicle-mediated transport [ISO]
- spindle assembly involved in mitosis [ISO]
- vesicle-mediated transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [IDA]
- cell [IMP]
- cleavage furrow [ISO]
- cytoplasm [IDA]
- cytoplasmic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IBA]
- kinetochore microtubule [ISO]
- membrane [IDA]
- mitochondrion [IDA]
- multivesicular body [ISO]
- perinuclear region of cytoplasm [IDA]
- phagocytic vesicle [ISO]
- protein complex [ISO]
- recycling endosome [IDA, ISO]
- spindle pole [ISO]
- trans-Golgi network [ISO]
- transport vesicle [ISO]
- vesicle [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival.
Photoreceptor cell death is the hallmark of a group of human inherited retinal degeneration. Although the causative genetic mutations are often known, the mechanisms leading to photoreceptor degeneration remain poorly defined. Here, we show that Semaphorin 4A (Sema4A), a member of axonal guidance molecule semaphorin, plays a role in Rab11/FIP2-mediated endosomal sorting in retinal pigment epithelial cells to support photoreceptor ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID