KCNA5
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [ISO]
- membrane hyperpolarization [ISO]
- negative regulation of cytosolic calcium ion concentration [IMP]
- negative regulation of potassium ion transport [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [IDA]
- positive regulation of myoblast proliferation [IDA]
- potassium ion export [ISO]
- potassium ion homeostasis [IMP]
- potassium ion transmembrane transport [IBA, ISO]
- potassium ion transport [IMP, ISO]
- protein oligomerization [IMP]
- regulation of atrial cardiac muscle cell membrane repolarization [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of membrane potential [IMP, ISO]
- regulation of potassium ion transport [ISO]
- regulation of vasoconstriction [ISO]
- response to hydrogen peroxide [IEP]
- response to hyperoxia [IEP]
- response to hypoxia [IEP]
- response to mechanical stimulus [IEP]
- response to organic substance [IEP]
Gene Ontology Molecular Function- alpha-actinin binding [ISO]
- delayed rectifier potassium channel activity [IBA, ISO]
- outward rectifier potassium channel activity [IMP, ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [IPI]
- scaffold protein binding [ISO]
- voltage-gated potassium channel activity [ISO]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [ISO]
- alpha-actinin binding [ISO]
- delayed rectifier potassium channel activity [IBA, ISO]
- outward rectifier potassium channel activity [IMP, ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [IPI]
- scaffold protein binding [ISO]
- voltage-gated potassium channel activity [ISO]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Z disc [IDA]
- endoplasmic reticulum [IDA]
- integral component of membrane [IBA]
- intercalated disc [IDA, ISO]
- intracellular canaliculus [IDA]
- membrane [ISO]
- membrane raft [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- voltage-gated potassium channel complex [ISO]
PRKCZ
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IMP]
- activation of phospholipase D activity [IMP]
- activation of protein kinase B activity [IMP]
- cell migration [IMP]
- cell surface receptor signaling pathway [IMP]
- cellular protein localization [IMP]
- cellular response to insulin stimulus [IMP]
- establishment of cell polarity [IMP]
- insulin receptor signaling pathway [IMP]
- intracellular signal transduction [IDA]
- long-term memory [IMP]
- long-term synaptic potentiation [IMP]
- membrane depolarization [IMP]
- membrane hyperpolarization [IMP]
- microtubule cytoskeleton organization [ISO]
- negative regulation of apoptotic process [IDA]
- negative regulation of hydrolase activity [IDA]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron projection extension [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of T-helper 2 cell cytokine production [ISO, ISS]
- positive regulation of T-helper 2 cell differentiation [ISO, ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of glucose import [IMP]
- positive regulation of insulin receptor signaling pathway [IMP]
- positive regulation of interleukin-10 secretion [ISO, ISS]
- positive regulation of interleukin-13 secretion [ISO, ISS]
- positive regulation of interleukin-4 production [ISO, ISS]
- positive regulation of interleukin-5 secretion [ISO, ISS]
- positive regulation of protein transport [IMP]
- positive regulation of synaptic transmission [IMP]
- protein heterooligomerization [IPI]
- protein kinase C signaling [IMP]
- protein localization to plasma membrane [ISO]
- protein phosphorylation [IDA, ISO]
- signal transduction [IDA]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- 14-3-3 protein binding [IPI]
- ATP binding [IDA]
- phospholipase binding [IPI]
- potassium channel regulator activity [IMP]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase C activity [IDA]
- protein kinase activity [ISO, TAS]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
- apical cortex [ISO]
- apical plasma membrane [ISO]
- axon hillock [ISO]
- cell cortex [ISO]
- cell leading edge [IDA]
- cell-cell junction [ISO, ISS]
- cytoplasm [IDA, ISO]
- cytosol [IDA, TAS]
- extracellular vesicular exosome [ISO]
- filamentous actin [IDA]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- microtubule organizing center [ISO]
- myelin sheath abaxonal region [ISO]
- nuclear envelope [ISO]
- nuclear matrix [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- tight junction [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Role of protein kinase Czeta and its adaptor protein p62 in voltage-gated potassium channel modulation in pulmonary arteries.
Voltage-gated potassium (K(V)) channels play an essential role in regulating pulmonary artery function, and they underpin the phenomenon of hypoxic pulmonary vasoconstriction. Pulmonary hypertension is characterized by inappropriate vasoconstriction, vascular remodeling, and dysfunctional K(V) channels. In the current study, we aimed to elucidate the role of PKCzeta and its adaptor protein p62 in the modulation of K(V) channels. We report ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRKCZ KCNA5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID