DDR1
Gene Ontology Biological Process
- cell adhesion [TAS]
- collagen-activated tyrosine kinase receptor signaling pathway [IDA, IMP]
- extracellular matrix organization [TAS]
- peptidyl-tyrosine autophosphorylation [IDA]
- protein autophosphorylation [IDA]
- regulation of extracellular matrix disassembly [IMP]
- smooth muscle cell migration [IMP]
- smooth muscle cell-matrix adhesion [IMP]
- wound healing, spreading of cells [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDH2
Gene Ontology Biological Process
- adherens junction organization [TAS]
- cell adhesion [TAS]
- cell junction assembly [TAS]
- cell-cell adhesion mediated by cadherin [ISS]
- cell-cell junction organization [TAS]
- glial cell differentiation [ISS]
- muscle cell differentiation [TAS]
- neuronal stem cell maintenance [ISS]
- positive regulation of muscle cell differentiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation.
The stabilization of cell surface E-cadherin is important for the maintenance of apical junction complexes and epithelial polarity. Previously, we reported that discoidin domain receptor 1 (DDR1) forms a complex with E-cadherin at adhesive contacts; however, the regulatory role of DDR1 in the stabilization of cell surface E-cadherin and E-cadherin-mediated cell behaviors remained undefined. To gain insight into these questions, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID