TBC1D1
Gene Ontology Biological Process
Gene Ontology Molecular Function
RAB14
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Golgi to endosome transport [IMP]
- Rab protein signal transduction [IBA]
- apical protein localization [ISO]
- body fluid secretion [ISO]
- embryo development [IMP]
- endocytic recycling [ISO]
- fibroblast growth factor receptor signaling pathway [IMP]
- intracellular protein transport [IBA]
- phagolysosome assembly involved in apoptotic cell clearance [IBA]
- regulation of protein localization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IBA]
- Golgi stack [ISO]
- alveolar lamellar body [ISO]
- apical plasma membrane [ISO]
- cell [IMP]
- cytoplasm [IMP]
- cytosol [ISO]
- early endosome [IBA, ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP, ISO]
- intracellular membrane-bounded organelle [ISO]
- late endosome [ISO]
- lysosomal membrane [ISO]
- lysosome [ISO]
- nuclear outer membrane-endoplasmic reticulum membrane network [ISO]
- perinuclear region of cytoplasm [ISO]
- phagocytic vesicle [IBA, ISO]
- plasma membrane [ISO]
- recycling endosome [ISO]
- rough endoplasmic reticulum [ISO]
- trans-Golgi network transport vesicle [ISO]
- transport vesicle [ISO]
Biochemical Activity
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
We have solved the x-ray crystal structures of the RabGAP domains of human TBC1D1 and human TBC1D4 (AS160), at 2.2 and 3.5 A resolution, respectively. Like the yeast Gyp1p RabGAP domain, whose structure was solved previously in complex with mouse Rab33B, the human TBC1D1 and TBC1D4 domains both have 16 α-helices and no β-sheet elements. We expected the yeast Gyp1p ... [more]
Throughput
- Low Throughput
Additional Notes
- Figure 4
- RabGAPs hydrolyzed Rab14-GTP in vitro
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TBC1D1 RAB14 | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | - |
Curated By
- BioGRID