BAIT
CDK2
CDKN2, p33(CDK2)
cyclin-dependent kinase 2
GO Process (16)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- DNA replication [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- G2/M transition of mitotic cell cycle [NAS, TAS]
- Ras protein signal transduction [IEP]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- blood coagulation [TAS]
- cellular response to nitric oxide [TAS]
- centrosome duplication [TAS]
- histone phosphorylation [IDA]
- meiotic nuclear division [TAS]
- mitotic G1 DNA damage checkpoint [TAS]
- mitotic cell cycle [TAS]
- positive regulation of cell proliferation [IDA]
- regulation of gene silencing [IDA]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPL37
L37
ribosomal protein L37
GO Process (13)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- translation [NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an endogenous secreted peptide and, in preclinical studies, preferentially induces apoptosis in tumor cells rather than in normal cells. The acquisition of resistance in cells exposed to TRAIL or its mimics limits their clinical efficacy. Because kinases are intimately involved in the regulation of apoptosis, we systematically characterized kinases involved in TRAIL signaling. ... [more]
Sci Signal Apr. 09, 2015; 8(371);rs3 [Pubmed: 25852190]
Throughput
- High Throughput
Curated By
- BioGRID