CBLB
Gene Ontology Biological Process
- T cell activation [IMP]
- immune response [IMP]
- intracellular signal transduction [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of alpha-beta T cell proliferation [IMP]
- positive regulation of T cell anergy [IMP]
- positive regulation of protein catabolic process [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SMAD7
Gene Ontology Biological Process
- adherens junction assembly [ISO]
- artery morphogenesis [IMP]
- cellular protein complex localization [ISO]
- cellular response to transforming growth factor beta stimulus [IMP, ISO]
- intracellular signal transduction [ISO]
- negative regulation of BMP signaling pathway [IDA, ISO]
- negative regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- negative regulation of peptidyl-serine phosphorylation [IMP, ISO]
- negative regulation of peptidyl-threonine phosphorylation [IMP, ISO]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription by competitive promoter binding [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- negative regulation of ubiquitin-protein transferase activity [ISO]
- pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of cell-cell adhesion [IMP, ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- protein stabilization [ISO]
- regulation of activin receptor signaling pathway [ISO]
- regulation of cardiac muscle contraction [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IC, ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [IC]
- transforming growth factor beta receptor signaling pathway [IDA]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- I-SMAD binding [ISO]
- activin binding [ISO]
- beta-catenin binding [ISO]
- collagen binding [IPI]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- I-SMAD binding [ISO]
- activin binding [ISO]
- beta-catenin binding [ISO]
- collagen binding [IPI]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.
T cell-intrinsic transforming growth factor beta (TGFβ) receptor signaling plays an essential role in controlling immune responses. The RING-type E3 ligase Cbl-b has been shown to mediate sensitivity of T cells to TGFβ; however, the mechanism underlying this process is unknown. This study shows that SMAD7, an established negative regulator of TGFβ receptor (TGFβR) signaling, is a key downstream effector ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 4. E2 (UbcH10)-mediated SMAD7 ubiquitination.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SMAD7 CBLB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 872447 |
Curated By
- BioGRID