CBLB
Gene Ontology Biological Process
- T cell activation [IMP]
- immune response [IMP]
- intracellular signal transduction [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of alpha-beta T cell proliferation [IMP]
- positive regulation of T cell anergy [IMP]
- positive regulation of protein catabolic process [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UBE2C
Gene Ontology Biological Process
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IBA, ISO]
- exit from mitosis [ISO]
- free ubiquitin chain polymerization [ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [ISO]
- positive regulation of exit from mitosis [ISO]
- protein K11-linked ubiquitination [ISO]
- protein K48-linked ubiquitination [ISO]
- protein polyubiquitination [IBA]
- protein ubiquitination [ISO]
- regulation of mitotic metaphase/anaphase transition [IBA]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.
T cell-intrinsic transforming growth factor beta (TGFβ) receptor signaling plays an essential role in controlling immune responses. The RING-type E3 ligase Cbl-b has been shown to mediate sensitivity of T cells to TGFβ; however, the mechanism underlying this process is unknown. This study shows that SMAD7, an established negative regulator of TGFβ receptor (TGFβR) signaling, is a key downstream effector ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 4. E2 (UbcH10)-mediated SMAD7 ubiquitination.
Curated By
- BioGRID