BAIT
TRIM63
MuRF1, RF1, Rnf28
tripartite motif-containing 63
GO Process (7)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- cellular response to dexamethasone stimulus [IDA]
- muscle contraction [ISA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein ubiquitination [IDA]
- regulation of gene expression [IMP]
- response to denervation involved in regulation of muscle adaptation [IDA]
- response to electrical stimulus involved in regulation of muscle adaptation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MYOM1
D430047A17Rik
myomesin 1
GO Process (1)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.
Loss of myofibrillar proteins is a hallmark of atrophying muscle. Expression of muscle RING-finger 1 (MuRF1), a ubiquitin ligase, is markedly induced during atrophy, and MuRF1 deletion attenuates muscle wasting. We generated mice expressing a Ring-deletion mutant MuRF1, which binds but cannot ubiquitylate substrates. Mass spectrometry of the bound proteins in denervated muscle identified many myofibrillar components. Upon denervation or ... [more]
J. Cell Biol. Jun. 15, 2009; 185(6);1083-95 [Pubmed: 19506036]
Throughput
- Low Throughput
Additional Notes
- Table 1
Curated By
- BioGRID