An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain.

Urena JM, La Torre A, Martinez A, Lowenstein E, Franco N, Winsky-Sommerer R, Fontana X, Casaroli-Marano R, Ibanez-Sabio MA, Pascual M, Del Rio JA, de Lecea L, Soriano E

Cytosolic tyrosine kinases play a critical role both in neural development and in adult brain function and plasticity. Here we isolated a cDNA with high homology to human Ack1 and mouse Tnk2. This cDNA directs the expression of a 125-kD protein that can be autophosphorylated in tyrosines. Initially, this clone was named Pyk1 for proline-rich tyrosine kinase (Lev et al., ... [more]

J. Comp. Neurol. Sep. 19, 2005; 490(2);119-32 [Pubmed: 16052498]

Throughput

Low Throughput

Additional Notes

Figure 1
autophosphorylation

Curated By

BioGRID

Interaction Summary

TNK2

Gene Ontology Biological Process

Gene Ontology Molecular Function

WW domain binding [ISO]epidermal growth factor receptor binding [ISO]hormone receptor binding [IBA]non-membrane spanning protein tyrosine kinase activity [IBA]protein serine/threonine/tyrosine kinase activity [ISO]protein tyrosine kinase activity [IDA, ISO]

Gene Ontology Cellular Component