UBE2B
Gene Ontology Biological Process
- DNA repair [IBA, ISO]
- canonical Wnt signaling pathway [IMP]
- cellular response to DNA damage stimulus [ISO]
- chiasma assembly [IMP]
- histone H2A ubiquitination [ISO]
- histone lysine demethylation [IMP]
- histone ubiquitination [IBA]
- in utero embryonic development [IGI]
- maintenance of chromatin silencing [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cAMP-mediated signaling [ISO]
- negative regulation of histone phosphorylation [IMP]
- positive regulation of reciprocal meiotic recombination [IMP]
- postreplication repair [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA, ISO]
- protein K11-linked ubiquitination [ISO]
- protein K48-linked ubiquitination [ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein monoubiquitination [ISO]
- protein polyubiquitination [IBA, ISO]
- protein stabilization [ISO]
- protein ubiquitination [IGI, ISO]
- regulation of histone modification [IMP]
- response to UV [ISO]
- response to drug [ISO]
- sperm axoneme assembly [IMP]
- spermatogenesis [IMP]
- synaptonemal complex organization [IMP]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
HIST2H2BB
Gene Ontology Cellular Component
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation.
We have isolated by differential RNA display a cDNA that is up-regulated in metastatic mammary tumor lines. This cDNA corresponds to HR6B, the yeast homologue of Rad6, a ubiquitin-conjugating enzyme, and a key player in postreplication repair and induced mutagenesis in the yeast. We show that Rad6 protein expressed in metastatic tumor lines is wild type and functional, because it ... [more]
Throughput
- Low Throughput
Additional Notes
- Antibody to Rad6 recognized Rad6A and B gene products
- Figure 3
- Immuniprecipitated human Rad6 ubiquitinated histone in vitro
Curated By
- BioGRID