BAIT
AXIN1
AI316800, Axin, Fu, Kb, Ki, fused, kinky, knobbly
axin 1
GO Process (53)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IPI, ISO]
- Wnt signaling pathway involved in somitogenesis [IBA]
- Wnt-activated signaling pathway involved in forebrain neuron fate commitment [IBA]
- activation of JUN kinase activity [IBA]
- activation of protein kinase activity [ISO]
- adult walking behavior [IMP]
- axial mesoderm development [IMP]
- axial mesoderm formation [IMP]
- canonical Wnt signaling pathway [IDA, IMP]
- canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [IBA]
- cell death [IBA]
- cellular protein complex assembly [ISO]
- cellular response to organic cyclic compound [IBA]
- cytoplasmic microtubule organization [IGI]
- determination of left/right symmetry [IBA]
- dorsal/ventral axis specification [IDA, ISO]
- dorsal/ventral pattern formation [IMP, ISO]
- embryonic eye morphogenesis [IBA]
- embryonic skeletal joint morphogenesis [IMP]
- erythrocyte homeostasis [IMP]
- forebrain anterior/posterior pattern specification [IBA]
- genetic imprinting [IMP]
- hemoglobin metabolic process [IMP]
- in utero embryonic development [IGI, IMP]
- muscle cell development [IBA]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of protein metabolic process [IDA]
- negative regulation of transcription elongation from RNA polymerase II promoter [IDA]
- neurological system process [IMP]
- nucleocytoplasmic transport [IDA]
- olfactory placode formation [IBA]
- optic placode formation [IBA]
- positive regulation of GTPase activity [IBA]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IDA, IMP, ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [IDA, ISO]
- positive regulation of protein ubiquitination [IDA, IGI, IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA, IGI, IMP]
- positive regulation of ubiquitin-protein transferase activity [IMP, ISO]
- post-anal tail morphogenesis [IMP]
- protein catabolic process [IDA]
- protein homooligomerization [IDA, ISO]
- protein polyubiquitination [IDA]
- regulation of catenin import into nucleus [IDA]
- regulation of protein phosphorylation [IGI]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function- GTPase activator activity [IBA]
- I-SMAD binding [IDA, IPI, ISO]
- R-SMAD binding [IPI]
- SMAD binding [ISO]
- armadillo repeat domain binding [IBA, ISO]
- beta-catenin binding [IMP, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IPI, ISO]
- p53 binding [IPI]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein complex scaffold [IMP, ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI, ISO]
- protein self-association [IPI]
- receptor binding [ISO]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- GTPase activator activity [IBA]
- I-SMAD binding [IDA, IPI, ISO]
- R-SMAD binding [IPI]
- SMAD binding [ISO]
- armadillo repeat domain binding [IBA, ISO]
- beta-catenin binding [IMP, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IPI, ISO]
- p53 binding [IPI]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein complex scaffold [IMP, ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI, ISO]
- protein self-association [IPI]
- receptor binding [ISO]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- beta-catenin destruction complex [IDA, ISO]
- cell cortex [IDA]
- cell periphery [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic microtubule [IDA]
- cytoplasmic vesicle [ISO]
- lateral plasma membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IBA, ISO]
- protein complex [IDA]
Mus musculus
PREY
PIAS4
PIASY, Pias-gamma, Piasg
protein inhibitor of activated STAT 4
GO Process (10)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- JAK-STAT cascade [ISA]
- multicellular organismal development [NAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of nucleic acid-templated transcription [ISA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- positive regulation of keratinocyte apoptotic process [IDA]
- positive regulation of protein sumoylation [ISO]
- protein sumoylation [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling.
Axin is a multifunctional protein, regulating Wnt signaling and the c-Jun N-terminal/stress-activated protein kinase (JNK/SAPK) pathway as well as tumorigenesis. In the present study, we found that Axin interacts with three SUMO-1 (small ubiquitin-related modifier) conjugating enzymes 3 (E3), PIAS1, PIASxbeta, and PIASy. The extreme C-terminal six amino acid residues of Axin are critical for the Axin/E3 interaction as deletion ... [more]
J. Biol. Chem. Nov. 08, 2002; 277(45);42981-6 [Pubmed: 12223491]
Throughput
- Low Throughput
Additional Notes
- Figure 1
Curated By
- BioGRID