TNFAIP3
Gene Ontology Biological Process
- B-1 B cell homeostasis [IMP]
- cellular response to hydrogen peroxide [IMP]
- cellular response to lipopolysaccharide [ISO]
- establishment of protein localization to vacuole [IDA]
- marginal zone B cell differentiation [NAS]
- negative regulation of B cell activation [IDA]
- negative regulation of CD40 signaling pathway [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of autophagy [NAS]
- negative regulation of cell death [IMP]
- negative regulation of chronic inflammatory response [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of endothelial cell apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO, NAS]
- negative regulation of granuloma formation [NAS]
- negative regulation of heterotypic cell-cell adhesion [NAS]
- negative regulation of inflammatory response [IDA, IMP]
- negative regulation of innate immune response [IMP]
- negative regulation of interleukin-1 beta production [IMP]
- negative regulation of interleukin-2 production [ISO]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [IMP]
- negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of toll-like receptor 3 signaling pathway [ISO]
- negative regulation of toll-like receptor 5 signaling pathway [IDA]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of cellular protein catabolic process [IDA]
- positive regulation of hepatocyte proliferation [IDA]
- positive regulation of protein catabolic process [ISO]
- protein K11-linked deubiquitination [ISO]
- protein K48-linked deubiquitination [ISO]
- protein K48-linked ubiquitination [ISO]
- protein K63-linked deubiquitination [IDA, ISO]
- protein deubiquitination [IDA]
- proteolysis [ISO]
- regulation of germinal center formation [IMP]
- regulation of immunoglobulin production [IC]
- regulation of innate immune response [IC]
- response to molecule of bacterial origin [IDA, ISO]
- response to muramyl dipeptide [IMP]
- response to wounding [NAS]
- tolerance induction to lipopolysaccharide [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme.
A20 is an anti-inflammatory protein linked to multiple human autoimmune diseases and lymphomas. A20 possesses a deubiquitinating motif and a zinc finger, ZF4, that binds ubiquitin and supports its E3 ubiquitin ligase activity. To understand how these activities mediate A20's physiological functions, we generated two lines of gene-targeted mice, abrogating either A20's deubiquitinating activity (Tnfaip3(OTU) mice) or A20's ZF4 (Tnfaip3(ZF4) ... [more]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- Likely protein-protein interaction
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBC TNFAIP3 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | High | - | BioGRID | 2297130 |
Curated By
- BioGRID