PPP2CA
Gene Ontology Biological Process
- cellular response to glucose stimulus [ISO]
- mesoderm development [IMP]
- negative regulation of calcium ion transmembrane transporter activity [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription factor import into nucleus [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein phosphatase type 2A activity [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- protein dephosphorylation [ISO, TAS]
- protein heterotrimerization [ISO]
- regulation of cell cycle [TAS]
- regulation of protein autophosphorylation [ISO]
- regulation of protein catabolic process [ISO]
- regulation of protein phosphorylation [ISO]
- regulation of receptor activity [ISO]
Gene Ontology Molecular Function- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
- GABA receptor binding [IDA]
- enzyme binding [ISO]
- ion channel binding [ISO]
- protein C-terminus binding [IPI, ISO]
- protein antigen binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein dimerization activity [ISO]
- protein domain specific binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- protein phosphatase binding [ISO]
- protein serine/threonine phosphatase activity [ISO, TAS]
- tau protein binding [ISO]
Gene Ontology Cellular Component
UNC5B
Gene Ontology Biological Process
- anterior/posterior axon guidance [IMP]
- axon guidance [ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO]
- netrin-activated signaling pathway [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase.
The UNC5H dependence receptors promote apoptosis in the absence of their ligand, netrin-1, and this is important for neuronal and vascular development and for limitation of cancer progression. UNC5H2 (also called UNC5B) triggers cell death through the activation of the serine-threonine protein kinase DAPk. While performing a siRNA screen to identify genes implicated in UNC5H-induced apoptosis, we identified the structural ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID