BAIT
BAP1
2300006C11Rik, AA989761, AW553466, mKIAA0272, uch-x4
Brca1 associated protein 1
GO Process (8)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- monoubiquitinated histone H2A deubiquitination [ISO]
- monoubiquitinated protein deubiquitination [ISO]
- negative regulation of cell proliferation [ISA]
- protein K48-linked deubiquitination [ISO]
- protein deubiquitination [ISA, ISO]
- proteolysis [ISO]
- regulation of cell cycle [ISO]
- regulation of cell growth [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- PR-DUB complex [ISO]
- cytoplasm [ISO]
- nucleoplasm [ISO]
- nucleus [ISA, ISO]
Mus musculus
PREY
PRKCA
AI875142, Pkca, RP23-145G23.2
protein kinase C, alpha
GO Process (51)
GO Function (7)
GO Component (18)
Gene Ontology Biological Process
- cellular calcium ion homeostasis [IMP]
- cellular response to carbohydrate stimulus [IDA]
- central nervous system neuron axonogenesis [ISO]
- chondrocyte differentiation [IDA]
- desmosome assembly [ISO]
- histone H3-T6 phosphorylation [ISO]
- inactivation of MAPK activity [IMP]
- induction of positive chemotaxis [IMP]
- intracellular signal transduction [ISO]
- intrinsic apoptotic signaling pathway [IMP]
- learning or memory [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glial cell apoptotic process [ISO]
- negative regulation of glucose import [IMP]
- negative regulation of heart contraction [ISO]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of protein kinase activity [IMP]
- negative regulation of protein phosphorylation [IGI, IMP]
- negative regulation of translation [ISO]
- neutrophil chemotaxis [IMP]
- peptidyl-serine autophosphorylation [IDA]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cardiac muscle hypertrophy [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of dense core granule biogenesis [IMP]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of exocytosis [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [ISO]
- positive regulation of macrophage differentiation [IMP]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of synapse assembly [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of muscle contraction [IMP]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- regulation of platelet aggregation [IMP, ISO]
- regulation of receptor-mediated endocytosis [ISO]
- regulation of the force of heart contraction [IMP]
- response to estradiol [ISO]
- response to ethanol [ISO]
- response to interleukin-1 [ISO]
- response to reactive oxygen species [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical part of cell [IDA]
- cell [IMP]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- dendrite [IDA]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrion [IDA, ISO]
- neuron projection [ISO]
- neuronal cell body [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- photoreceptor outer segment [IDA]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Loss of the tumor suppressor BAP1 causes myeloid transformation.
De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies. We show that mouse Bap1 gene deletion is lethal during embryogenesis, but systemic or hematopoietic-restricted deletion in adults recapitulates features of human myelodysplastic syndrome (MDS). Knockin mice expressing BAP1 with a 3xFlag tag revealed that ... [more]
Science Sep. 21, 2012; 337(6101);1541-6 [Pubmed: 22878500]
Throughput
- Low Throughput
Curated By
- BioGRID