BAIT
BAP1
2300006C11Rik, AA989761, AW553466, mKIAA0272, uch-x4
Brca1 associated protein 1
GO Process (8)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- monoubiquitinated histone H2A deubiquitination [ISO]
- monoubiquitinated protein deubiquitination [ISO]
- negative regulation of cell proliferation [ISA]
- protein K48-linked deubiquitination [ISO]
- protein deubiquitination [ISA, ISO]
- proteolysis [ISO]
- regulation of cell cycle [ISO]
- regulation of cell growth [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- PR-DUB complex [ISO]
- cytoplasm [ISO]
- nucleoplasm [ISO]
- nucleus [ISA, ISO]
Mus musculus
PREY
PIP5K1C
AI115456, AI835305, Pip5kIgamma
phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma
GO Process (5)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Loss of the tumor suppressor BAP1 causes myeloid transformation.
De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies. We show that mouse Bap1 gene deletion is lethal during embryogenesis, but systemic or hematopoietic-restricted deletion in adults recapitulates features of human myelodysplastic syndrome (MDS). Knockin mice expressing BAP1 with a 3xFlag tag revealed that ... [more]
Science Sep. 21, 2012; 337(6101);1541-6 [Pubmed: 22878500]
Throughput
- Low Throughput
Curated By
- BioGRID