VAC14
Gene Ontology Cellular Component
NOS1
Gene Ontology Biological Process
- aging [IEP]
- arginine catabolic process [IDA]
- behavioral response to cocaine [IMP]
- cellular response to epinephrine stimulus [IMP]
- cellular response to growth factor stimulus [ISO]
- cellular response to mechanical stimulus [IMP]
- exogenous drug catabolic process [ISO]
- female pregnancy [IEP]
- multicellular organismal response to stress [ISO]
- muscle contraction [IBA]
- negative regulation of apoptotic process [IMP]
- negative regulation of blood pressure [IMP]
- negative regulation of calcium ion transport [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of cytosolic calcium ion concentration [IMP]
- negative regulation of heart contraction [IMP]
- negative regulation of hydrolase activity [ISO]
- negative regulation of insulin secretion [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- negative regulation of potassium ion transport [ISO]
- negative regulation of serotonin uptake [ISO]
- negative regulation of vasoconstriction [IMP]
- nitric oxide biosynthetic process [IDA, ISO]
- nitric oxide mediated signal transduction [IBA, IMP]
- peptidyl-cysteine S-nitrosylation [IDA, ISO]
- positive regulation of adrenergic receptor signaling pathway involved in heart process [ISO]
- positive regulation of guanylate cyclase activity [IBA]
- positive regulation of histone acetylation [ISO]
- positive regulation of long-term synaptic potentiation [IMP]
- positive regulation of neuron death [IMP]
- positive regulation of sodium ion transmembrane transport [IMP]
- positive regulation of the force of heart contraction [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of vasodilation [IMP, ISO]
- regulation of heart contraction [IMP]
- regulation of sensory perception of pain [IMP]
- regulation of sodium ion transport [ISO]
- response to activity [IEP]
- response to estrogen [IDA]
- response to ethanol [IEP]
- response to heat [IEP, ISO]
- response to hypoxia [IEP, ISO]
- response to lead ion [IEP]
- response to lipopolysaccharide [IEP]
- response to nicotine [IEP]
- response to nitric oxide [IEP]
- response to nutrient levels [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IMP]
- response to vitamin E [IEP]
- striated muscle contraction [ISO]
Gene Ontology Molecular Function- ATPase binding [IPI]
- FMN binding [IDA, TAS]
- NADP binding [IDA, TAS]
- NADPH-hemoprotein reductase activity [IBA]
- amino acid binding [TAS]
- cadmium ion binding [IDA]
- calmodulin binding [IDA]
- enzyme binding [IPI]
- flavin adenine dinucleotide binding [IDA, TAS]
- heme binding [IDA, TAS]
- ion channel binding [IPI]
- nitric-oxide synthase activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- scaffold protein binding [IPI]
- sodium channel regulator activity [IMP]
- ATPase binding [IPI]
- FMN binding [IDA, TAS]
- NADP binding [IDA, TAS]
- NADPH-hemoprotein reductase activity [IBA]
- amino acid binding [TAS]
- cadmium ion binding [IDA]
- calmodulin binding [IDA]
- enzyme binding [IPI]
- flavin adenine dinucleotide binding [IDA, TAS]
- heme binding [IDA, TAS]
- ion channel binding [IPI]
- nitric-oxide synthase activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- scaffold protein binding [IPI]
- sodium channel regulator activity [IMP]
Gene Ontology Cellular Component
- azurophil granule [IDA]
- cytoplasm [IDA]
- cytoskeleton [ISO]
- cytosol [IDA]
- dendrite [IDA]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrial outer membrane [IDA]
- mitochondrion [IDA]
- nuclear membrane [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- photoreceptor inner segment [IDA]
- plasma membrane [IDA]
- postsynaptic density [IDA]
- protein complex [IDA]
- sarcolemma [IDA, ISO]
- sarcoplasmic reticulum [ISO]
- synapse [IDA, ISO]
- vesicle membrane [IDA]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif.
PDZ domains mediate protein interactions primarily through either classical recognition of carboxyl-terminal motifs or PDZ/PDZ domain associations. Several studies have also described internal modes of PDZ recognition, most of which depend on beta-finger structures. Here, we describe a novel interaction between the PDZ domain of nNOS and Vac14, the activator of the PtdIns(3)P 5-kinase PIKfyve. Binding assays using various Vac14 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VAC14 NOS1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID